We offer an internationally renowned critical care research program with a range of outputs ranging from new drugs and devices, novel insights into the pathophysiology underlying critical illness, and a very active experimental and clinical research portfolio.
This is reflected in significant grant funding, multiple publications in high impact factor journals, new patents and national/international awards and prizes.
Our educational output extends from textbooks (e.g. Oxford Handbook of Critical Care) to long-running courses in medical emergencies.
Research Interests and Techniques
1 – Pathophysiology of critical illness
mitochondrial dysfunction in critical illness
mechanisms of acute renal injury
nitrite reductase activity in sepsis and hypoxaemia
2 – Novel monitoring and diagnostics
tissue PO2 monitoring as a marker of local oxygen supply adequacy in shock states
NADH redox state as a marker of the adequacy of tissue perfusion
novel haemodynamic monitoring parameters using linked oesophageal Doppler ultrasound and blood pressure monitoring
novel biomarkers for early detection of sepsis and infection
development of a critical illness stress index
3 – Novel interventions
long-acting sulphide donor therapy for ischaemia-reperfusion injury
beta-blocker therapy in severe sepsis
activators of mitochondrial biogenesis to enhance recovery from critical illness