Rupert Pearse

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Rupert Pearse

Rupert Pearse MD FRCA FFICM
Professor & Consultant in Intensive Care Medicine
Queen Marys University of London

Phone:+44 (0)20 3594 0346


Address: Adult Critical Care Unit, Royal London Hospital
Whitechapel, London, E1 1BB, United Kingdom

Region: London

Research type:  Major trials and observational studies; Health Services Research

Research Interests: Clinical effectiveness research in Critical Care Medicine and Peri-Operative Medicine

Key Techniques: 



  • National Institute for Health Research Research Professorhip
  • National Institute for Health Research Health Services & Delivery Research
  • British Journal of Anaesthesia / Royal College of Anaesthetists


Selected Publications (past five years):

  1. Pearse RM, Harrison DA, MacDonald N, Gillies MA, Blunt M, Ackland G, Grocott MP, Ahern A, Griggs K, Scott R, Hinds C, Rowan K; OPTIMISE Study Group. Effect of a perioperative, cardiac output-guided hemodynamic therapy algorithm on outcomes following major gastrointestinal surgery: a randomized clinical trial and systematic review. JAMA. 2014; 311: 2181-90.
  2. Baron D, Hochrieser H, Posch M, Metnitz B, Rhodes A, Moreno R, Pearse RM, Metnitz P. Preoperative anaemia is associated with higher in-hospital morbidity and mortality in non-cardiac surgery patients. Brit J Anaesth 2014 epub
  3. Prowle JR, Kolic I, Purdell-Lewis J, Taylor R, Pearse RM, Kirwan CJ. Serum Creatinine Changes Associated with Critical Illness and Detection of Persistent Renal Dysfunction after AKI. Clin J Am Soc Nephrol. 2014; 9:1015-23.
  4. Torrance HD, Brohi K, Pearse RM, Mein CA, Wozniak E, Prowle JR, Hinds CJ, OʼDwyer MJ. Association Between Gene Expression Biomarkers of Immunosuppression and Blood Transfusion in Severely Injured Polytrauma Patients. Ann Surg. 2014 epub.
  5. Botto F, Alonso-Coello P, Chan MT, Villar JC, Xavier D, Srinathan S, Guyatt G, Cruz P, Graham M, Wang CY, Berwanger O, Pearse RM, et al; on behalf of The Vascular events In noncardiac Surgery patIents cOhort evaluatioN (VISION) Investigators. Myocardial injury after noncardiac surgery: a large, international, prospective cohort study establishing diagnostic criteria, characteristics, predictors, and 30-day outcomes. Anesthesiology 2014;120: 564-78.
  6. James S, Jhanji S, Smith A, O’Brien G, Fitzgibbon M, Pearse RM. Comparison of the prognostic accuracy of scoring systems, cardio-pulmonary exercise testing and plasma biomarkers: A single centre observational pilot study. Brit J Anaesth 2014; 112: 491-7.
  7. Cullen M, Jhanji S, Pearse RM, Fitzgibbon M. Neutrophil Gelatinase-Associated Lipocalin as a predictor of acute kidney injury in patients treated with goal directed haemodynamic therapy after major abdominal surgery. Ann Clin Biochem 2014; 51: 392-9.
  8.  Lee GR, Jhanji S, Tarrant H, James S, Pearse RM, Fitzgibbon MC. Peri-operative troponin monitoring using a prototype high-sensitivity cardiac troponin I (hs-cTnI) assay: comparisons with hs-cTnT and contemporary cTnI assays. Ann Clin Biochem 2014; 51: 258-68.
  9.  Gillies M, Habicher M, Jhanji S, Sander M, Mythen M, Hamilton M, Pearse RM. Incidence of peri-operative death and kidney injury associated with 6% hydroxyethyl starch use: systematic review and meta-analysis. Brit J Anaesth 2014;112: 25-34.
  10.  Reynolds T, Vivian-Smith A, Jhanji S, Pearse RM. Observational study of the effects of age, diabetes mellitus, cirrhosis and chronic kidney disease on sublingual microvascular flow. Perioper Med 2013; 2: 7.
  11.  Walsh T, Boyd J, Watson D, Hope D, Lewis S, Krishan A, Forbes J, Ramsay P, Pearse RM, Wallis C, Cairns C, Cole S, Wyncoll D, for the RELIEVE investigators. Restrictive Versus Liberal Transfusion Strategies for Older Mechanically Ventilated Critically Ill Patients: A Randomized Pilot Trial. Crit Care Med 2013; 41(10):2354-63.
  12.  Bangash M, Patel N, Benetti E, Collino M, Hinds CJ, Thiemermann C, Pearse RM. Dopexamine can attenuate the inflammatory response and protect against organ injury in a rodent model of laparotomy and endotoxaemia in the absence of significant effects on haemodynamics or microvascular flow. Crit Care. 2013; 17: R57.
  13.  Pearse RM, Moreno R, Bauer P, Pelosi P, Metnitz P, Spies C, Vallet B, Vincent J-L, Hoeft A, Rhodes A. Mortality after surgery in Europe: a seven day cohort study. Lancet 2012; 380: 1059-65.
  14.  VISION Study Investigators, Devereaux PJ, Chan M, Alonso-Coello P, Walsh M, Berwanger O, Villar J, Wang C, Garutti R, Jacka M, Sigamani A, Srinathan S, Biccard B, Chow C, Abraham V, Tiboni M, Pettit S, Szczeklik W, Lurati Buse G, Botto F, Guyatt G, Heels-Ansdell D, Sessler D, Thorlund K, Garg A, Mrkobrada M, Thomas S, Rodseth R, Pearse RM, Thabane L, McQueen M, VanHelder T, Bhandari M, Bosch J, Kurz A, Polanczyk C, Malaga G, Nagele P, Le Manach Y, Leuwer M, Yusuf S. Association between postoperative troponin levels and 30-day mortality among patients undergoing noncardiac surgery. JAMA 2012; 307: 2295-304.
  15.  Young EL, Karthikesalingam A, Huddart S, Pearse RM, Hinchliffe RJ, Loftus IM, Thompson MM, Holt PJ. A systematic review of the role of cardiopulmonary exercise testing in vascular surgery. Eur J Vasc Endovasc Surg 2012; 44: 64-71.
  16.  Terblanche M, Kruger P, Gangi SD, Gearay S, Gilfeather L, Ferguson ND, Pearse RM, Beale R, Rhodes A, Brett SJ, McAuley DF. Risk factors for acute organ failure in intensive care unit patients who receive respiratory support in the absence of non-respiratory organ failure: an international prospective cohort study. Crit Care 2012; 16: R61.
  17.  Davenport R, Manson J, De’Ath H, Platton S, Coates A, Allard S, Hart D, Pearse RM, Pasi K, MacCallum P, Stanworth S, Brohi K. Functional definition and characterisation of Acute Traumatic Coagulopathy. Critical Care Med 2011; epub.
  18.  Kavsak PA, Walsh M, Srinathan S, [24 authors], Pearse RM, Rodseth RN, Sessler DI, Sigamani A, Szczeklik W, Tiboni M, Villar JC, Wang CY, Xavier S, Devereaux PJ. High Sensitivity Troponin T (TnT hs) concentrations in patients undergoing noncardiac surgery: A prospective cohort study.  Clin Biochem. 2011; 44:1021-4.
  19.  Davenport R, Curry N, Manson J, De’Ath H, Coates A, Rourke C, Pearse RM, Stanworth S, Brohi K. Hemostatic Effects of Fresh Frozen Plasma May be Maximal at Red Cell Ratios of 1:2. J Trauma 2011; 70: 90-96.
  20.  Martin-Loeches I, Lisboa T, Rhodes A, Moreno R, Silva E, Sprung C, Chiche J-D, Barahona D, Villabon D, Balasini C, Pearse RM, Rello J. Use of corticosteroid therapy in patients affected by severe pandemic (H1N1) influenza A infection. Intensive Care Med 2011; 37: 272-83.
  21.  Jhanji S, Vivian-Smith A, Lucena-Amaro S, Watson D, Hinds C, Pearse RM. Haemodynamic optimisation improves tissue microvascular flow and oxygenation
  22. after major surgery: A randomised controlled trial. Critical Care 2010; 14: R151.
  23.  Spanos A, Jhanji S, Smith A, Harris T, Pearse RM. Early microvascular changes in sepsis, severe sepsis and septic shock. Shock 2010; 33: 387-391.
  24.  MaddisonB, WolffC, Jones P, Findlay G, Radermacher P, Hinds C, Pearse RM. Comparison of three methods of extra-vascular lung water volume measurement in patients following cardiac surgery. Critical Care 2009; 13: R107.
  25.  Jhanji S, Stirling S, Patel N, Hinds C, Pearse RM. Effect of norepinephrine on microvascular perfusion and tissue oxygenation in septic shock. Critical Care Med 2009; 37:1961-6.
  26.  Jhanji S, Lee C, Watson D, Hinds CJ, Pearse RM. Tissue oxygenation and microvascular flow following major abdominal surgery. Intensive Care Med 2009; 35: 671-7.