Michael O’Dwyer

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Michael O’Dwyer

O Dwyer

Phone: +44 (0) 20 7377 7000

Email:  michael.odwyer@bartshealth.nhs.uk

Address: Adult Critical Care Unit
Level 4,
The Royal London Hospital
Whitechapel
London, E1 1BB

 

Region:  London

Research type: Clinical, Pre-Clinical

Research Interests:

  • Immunological, genetic and epigenetic factors in the susceptibility to develop hospital acquired infections in critically ill patients.
  • T cell maturation and the susceptibility to develop hospital acquired infections following elective major surgery.
  • Gene expression following uneventful cardiac surgery.
  • Inflammatory and immune mediators in high altitude performance.

Key Techniques: Immunogenetics

Keywords: Immunology, Trauma, sepsis

Funding: NIAA, ESICSM, ICS

Collaborations: Prof Charles Hinds (WHRI); Prof Karim Brohi (Blizzard Institute); Dr Rupert Pearse (Intensive Care Medicine).

Selected Publications:

  1.  Torrance HDT, Vivian M, Brohi K, Pearse RM, Owen HC, Hinds CJ, O’Dwyer MJ. The duration of storage of packed red blood cells prior to transfusion is associated with a characteristic gene expression pattern. J Trauma Acute Care Surg. 2014 In press.
  2. Fragou PC, Torrance HD, Pearse RM, Ackland GL, Prowle JR, Owen HC, Hinds CJ, O’Dwyer MJ. Perioperative blood transfusion is assocaited with a gene transcription profile characteristic of immunosuppression: a prospective cohort study. Crit Care 2014. Oct 1;18(5):541
  3. Torrance HDT, Brohi K, Pearse R, Mein CA, Wozniak E, Prowle JR, Hinds CJ, O’Dwyer MJ. Association between gene expression biomarkers of immunosuppression and blood transfusion in severely injured polytrauma patients. Ann Surg 2014 Mar 25.
  4. McMorrow RCN, Windsor JS, Hart ND et al. (2012). Closed and open breathing circuit function in healthy volunteers during exercise at Mount Everest base camp (5300 m). ANAESTHESIA Vol.67, (8) 0003-2409 875-880.
  5. White M, Martin-Loeches I, Lawless MW et al. (2011). Hospital-Acquired Pneumonia After Lung Resection Surgery Is Associated With Characteristic Cytokine Gene Expression. CHEST Vol.139, (3) 0012-3692 626-632.
  6. White M, O’Dwyer M, Grealy R et al. (2009). INTERLEUKIN 6 PROTEIN EXPRESSION IN HUMAN HOST RESPONSE TO INFECTION AND SEPSIS DISPLAYS DISTINCTIVE PROFILES. CRITICAL CARE MEDICINE Vol.37, (12) 0090-3493 A214-A214.
  7. White M, Grealy R, Lawless MW et al. (2009). APOPTOSIS MARKERS BIM AND BCL2 MRNA TRANSCRIPTION IN PERIPHERAL BLOOD MONONUCLEAR CELLS CAN DISTINGUISH BETWEEN THE HUMAN HOST RESPONSE IN INFECTION AND SEPSIS. INTENSIVE CARE MEDICINE Vol.35, () 0342-4642 168-168.
  8. White M, Grealy R, O’Dwyer M et al. (2008). IL1 beta AND IL17 GENE TRANSCRIPTION AND PROTEIN EXPRESSION IN HUMAN RESPONSE TO INFECTION.. CRITICAL CARE MEDICINE Vol.36, (12) 0090-3493 A30-A30.
  9. O’Dwyer MJ, Mankan AK, Ryan AW et al. (2008). Characterization of tumour necrosis factor-alpha genetic variants and mRNA expression in patients with severe sepsis. INTERNATIONAL JOURNAL OF IMMUNOGENETICS Vol.35, (4-5) 1744-3121 279-285.
  10. Lawless MW, White M, Mankan AK et al. (2007). Elevated MCP-1 serum levels are associated with the H63D mutation and not the C282Y mutation in hereditary hemochromatosis. TISSUE ANTIGENS Vol.70, (4) 0001-2815 294-300.
  11. Duggan E, Caraher E, Gately K et al. (2006). Tumor necrosis factor-alpha and interleukin-10 gene expression in peripheral blood mononuclear cells after cardiac surgery. CRITICAL CARE MEDICINE Vol.34, (8) 0090-3493 2134-2139.