John Simpson

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John Simpson

J SimpsonJohn Simpson

  • Lead for academic respiratory medicine, Newcastle University
  • Associate Dean for Clinical Research, Newcastle University
  • Clinical Director of Research and Development, Newcastle upon Tyne Hospitals (NuTH) NHS Foundation Trust.
  • Director of the NIHR Diagnostic Evidence Cooperatives (DEC) based in Newcastle. DECs were established in order to improve methodological evaluation, and implementation into practice, of in vitro diagnostics (IVDs). The Newcastle DEC welcomes and encourages contact from IVD companies and from academics with an interest in developing IVDs.
  • Chair, Research Review Panel, Asthma UK


Phone: 0191 208 7770


Address: 3rd Floor, William Leech Building
Medical School
Newcastle University
Framlington Place
Newcastle upon Tyne 

Region: Newcastle

Research type: Basic Science, Translational, Clinical

Research Interests:

  • Innate immune dysfunction in severe illness
  • Ventilator-acquired pneumonia (VAP)
  • ICU-acquired infection

 Key Techniques: 

  • Oesophageal manometry
  • Bronchoscopy and BAL
  • CT-PET




  • MRC Developmental Clinical Studies (DCS): Does GM-CSF restore effective neutrophil function in critically ill patients?
  • Wellcome Trust/Department of Health Health Innovation Challenge Fund (HICF): Rapid detection and treatment of ventilator-associated pneumonia – towards improved antibiotic stewardship
  • NIHR Diagnostic Evidence Co-operative Award
  • Newcastle Healthcare Charity Award – A lipopolysaccharide (LPS) inhalation model to characterise divergent cellular innate immune responses early in the course of acute lung inflammatio

Selected Previous

  • Sir Jules Thorn Charitable Trust Award for Biomedical Sciences 2003 
Acute infective lung injury: towards cell therapy with antiprotease-infected monocytes.
  • Sir Jules Thorn Charitable Trust 
A randomised controlled trial of monocyte depletion in acute neutrophil-mediated lung injury.


  • The VAPRapid project involves collaboration with investigators from 12 UK sites (Newcastle, Belfast, Birmingham, Chester, Coventry, Edinburgh, London (Chelsea & Westminster), Manchester, Newcastle, North Tyneside, Preston, Sunderland)
  • The GRiP project involves collaborations with ICUs in Gateshead, Newcastle and Sunderland
  • Other key collaborators include:
  • Professor Danny McAuley, Dr Cecilia O’Kane, Dr Ronan McMullan (Queen’s University Belfast)
  • Professor Adriano Rossi, Dr Donald Davidson, Dr Nik Hirani (Edinburgh University)
  • Professor Paul Corris, Dr Tony De Soyza, Dr Ian Forrest, Dr Sophie West, Dr Stephen Bourke, Dr Patrick Kesteven, Professor Patrick Chinnery, Professor Matt Collin, Professor John Dark, Dr Simon Baudouin, Dr Stephen Wright (Newcastle University)

Selected Publications