Ingeborg Welters

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Ingeborg Welters

Prof. Dr. med. habil.

Senior Clinical Lecturer, University of Liverpool

Honorary Consultant in Intensive Care, Royal Liverpool University Hospital

Honorary Professor of Anaesthesia and Intensive Care, Justus-Liebig Universität Giessen, Germany

Phone: 0151 706 3191 (secretary)

Email:  I.Welters@liverpool.ac.uk

Address: Royal Liverpool University Hospital, Intensive Care Unit, Prescot Street, L7 8XP, Liverpool

Region:  Cheshire and Merseyside

Research type: Translational Research, Clinical Research, Clinical Trials, Observational Studies

Research Interests: Sepsis, inflammation, immune response, prediction of outcome, opioids and analgesics, cardiac function and biomarkers, biomarkers of infection

Key Techniques:  Molecular biology, flow cytometry, immunoassays

Keywords:  Sepsis, neutrophils, coagulation, inflammation, immune response, prediction of outcome, opioids and analgesics, cardiac function, echocardiography, cardiac biomarkers, biomarkers of infection

 Funding: NIHR, British Heart Foundation

Collaborations:

  • Justus-Liebig-Universität Giessen, Germany
  • CNRS, Université de Strasbourg, France
  • Institute of Infection and Global Health, Institute of Translational Medicine, University of Liverpool, UK

Selected Publications:

  1. Steele T, Kolamunnage-Dona R, Downey C, Toh CH, Welters I. Assessment and clinical course of hypocalcemia in critical illness. Crit Care. 2013 Jun 4;17(3):R106
  2. Welters ID, Gibson J, Mogk M, Wenstone R. Major sources of critical incidents in intensive care. Crit Care. 2011;15(5):R232.
  3. Welters ID, Feurer MK, Preiss V, Müller M, Scholz S, Kwapisz M, Mogk M, Neuhäuser C. Continuous S-(+)-ketamine administration during elective coronary artery bypass graft surgery attenuates pro-inflammatory cytokine response during and after cardiopulmonary bypass. Br J Anaesth. 2011 Feb;106(2):172-9. Epub 2010 Dec 7
  4. Glattard E, Welters ID, Lavaux T, Muller A, Zhang D, Laux A, Schmidt AR, Delande F, Colin DA, Van Dorsselaer A, Aunis D, Metz-Boutigue MH, Schneider F, Goumon Y. Endogenous Morphine Levels are Increased in Sepsis. PlosOne 2010 Jan 20;5(1):e8791
  5. Welters ID, Hafer G, Menzebach A, Mühling J, Neuhäuser C, Browning P, Goumon Y. Ketamine inhibits transcription factors AP-1 and NF-κB, IL-8 production, as well as CD11b and CD16 expression: Studies in human leukocytes and leukocytic cell lines. Anesth Analg 2010;110:934-41
  6. Laux-Biehlmann A, Chung H, Mouheiche J, Vérièpe J, Delalande F, Lamshöft M, Welters ID, Soldevila S, Bazin H, Lamarque L, Van Dorsselaer A, Poisbeau P, Schneider F, Goumon Y, Garnero P. Endogenous morphine-6-glucuronide (M6G) is present in the plasma of patients: validation of a specific anti-M6G antibody for clinical and basic research. Biofactors. 2014 Jan-Feb;40(1):113-20
  7. Laux-Biehlmann A, Gräfe N, Mouheiche J, Stuber D, Welters ID, Delalande F, Poisbeau P, Garnero P, Metz-Boutigue MH, Schneider F, Goumon Y. Comparison of serum and lithium-heparinate plasma for the accurate measurements of endogenous and exogenous morphine concentrations. Br J Clin Pharmacol. 2012 Aug;74(2):381-3.
  8. Pérez-Casal M, Thompson V, Downey C, Welters I, Wyncoll D, Thachil J, Toh CH. The clinical and functional relevance of microparticles induced by activated protein C treatment in sepsis. Crit Care. 2011 Aug 11;15(4):R195.
  9. Matejec R, Löcke G, Kayser F, Lichtenstern C, Weigand MA, Welters ID, Bödeker RH, Harbach HW. Hemodynamic actions of corticotropin releasing hormone and proopiomelanocortin derivatives in septic patients. J Cardiovasc Pharmacol. 2011 Jan;57(1):94-102.
  10. Mathioudakis D, Engel J, Welters ID, Dehne MG, Matejec R, Harbach H, Henrich M, Schwandner T, Fuchs M, Weismüller K, Scheffer GJ, Mühling J. Pyruvate: immunonutritional effects on neutrophil intracellular amino or alpha-keto acid profiles and reactive oxygen species production. Amino Acids. 2011 Apr;40(4):1077-90. Epub 2010 Sep 14.